The ED management of patients with allergies and anaphylaxis is lacking evidence-based treatments. The St. Paul’s ED research group has been seeking to provide evidence to inform our management of this very common patient presentation. Published manuscripts have investigated the incidence of biphasic reactions and the potential benefit of glucocorticoids.
Grunau BE, Wiens MO, Rowe BH, McKay R, Li J, Yi TW, Stenstrom R, Schellenberg RR, Grafstein E, Scheuermeyer FX. Emergency Department Corticosteroid Use for Allergy or Anaphylaxis Is Not Associated With Decreased Relapses. Ann Emerg Med. 2015 Oct;66(4):381-9. doi: 10.1016/j.annemergmed.2015.03.003. PubMed PMID: 25820033.
Grunau BE, Scheuermeyer FX, Schellenberg RR. In reply. Ann Emerg Med. 2014 Dec;64(6):687-8. doi: 10.1016/j.annemergmed.2014.08.008. PubMed PMID: 25454573.
Grunau BE, Li J, Yi TW, Stenstrom R, Grafstein E, Wiens MO, Schellenberg RR, Scheuermeyer FX. Incidence of clinically important biphasic reactions in emergency department patients with allergic reactions or anaphylaxis. Ann Emerg Med. 2014 Jun;63(6):736-44.e2. doi: 10.1016/j.annemergmed.2013.10.017. PubMed PMID: 24239340.
In addition, we have contributed to the Canadian Society of Allergy and Clinical Immunology Anaphylaxis in Schools and Other Settings guideline.