The landmark article describing the “Pill-in-the-Pocket” approach to recurrent Atrial Fibrillation.  They conclude:

“In a selected, risk-stratified population of patients with recurrent atrial fibrillation, pill-in-the-pocket treatment is feasible and safe, with a high rate of compliance by patients, a low rate of adverse events, and a marked reduction in emergency room visits and hospital admissions.”

N Engl J Med 2004;351:2384-91. (Link)